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Mechanisms of DNA recombination and genome rearrangements

Mechanisms of DNA recombination and genome rearrangements

: Intersection between homologous recombination, DNA replication and DNA repair

by volume editor, Maria Spies, Anna Malkova
3rd March, 2018

£145.00 £145.00 Save 0% | Hardback


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Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.

Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.

Details & Specs

Series: Methods in enzymology


Author: Maria Spies Anna Malkova


Publisher: Academic Press


Format: Hardback


ISBN: 9780128139790


Publication Date: 3rd March, 2018


Pages: 2


Dimensions: 229 x 152 x 39 mm


Availability: Available, print on demand, usually dispatched within 7 to 10 days


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